TNF-SAM-2 |
TNFSF1 |
Spinorphin |
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A fusion protein comprising a single chain antibody (scFv) targeting module, a trimerization domain, and TNF-alpha. The fusion protein induces cell death in targeted cells expressing the two TNF receptors R1 and R2 and can be constructed in a way allowing site-specific proteolytic activation of TNF at tumor cells (Wüest et al, 2002).
See also: antibody fusion proteins.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.
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