TNF-alpha-inducing protein |
TNF-alpha-inhibiting factor |
GHI/61 |
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[tumor necrosis factor-alpha inhibitor] This factor of 33 kDa is isolated from the urine of febrile patients. It inhibits cytotoxicity in L929 cells induced by TNF-alpha. It also blocks prostaglandin E2 production and expression of cell-associated IL1 by human dermal fibroblasts, providing evidence for anti-inflammatory activity. Cytotoxicity induced by TNF-beta is only slightly affected by the inhibitor.
TNF-alpha INH blocks of TNF-alpha binding to the promonocytic cell line U937. Preincubation of TNF-alpha with the inhibitor increases binding inhibition, suggesting an interaction between
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