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TNF-alpha-inhibiting factor

abbr. TIF, which is used also as abbreviation for other factors.

This factor has been found in the conditioned medium of a macrophage tumor cell line (Baer et al, 1998). TIF negatively regulates expression of TNF-alpha induced by bacterial lipopolysaccharides in macrophages and enhances expression of IL1-beta, IL6, and MCP-1. TIF is distinct from the known TNF-alpha inhibiting factors IL4, IL10, and TGF-beta.

The action of TIF requires the selective induction of the p50 subunit of the transcription factor ... ... ... ... ... Subscribe to continue reading! ... ...

 

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