TNF-alpha INH |
TNF-alpha inhibitory protein B1 |
cis-NATs |
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abbr. TIF, which is used also as abbreviation for other factors.
This factor has been found in the conditioned medium of a macrophage tumor cell line (Baer et al, 1998). TIF negatively regulates expression of TNF-alpha induced by bacterial lipopolysaccharides in macrophages and enhances expression of IL1-beta, IL6, and MCP-1. TIF is distinct from the known TNF-alpha inhibiting factors IL4, IL10, and TGF-beta.
The action of TIF requires the selective induction of the p50 subunit of the transcription factor
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