TRAF-C domain |
TRAF domain encompassing factors |
IL1-beta converting enzyme-beta |
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[TRAF domains]
[TNF-receptor associated factor domain] This protein domain of approximately 180 amino acids is characteristic of all members of a group of signaling molecules designated TRAF, which are involved in signaling through the TNF receptor. All TRAF proteins share a common stretch of amino acids at their carboxyl terminus (Cao et al, 1996). The TRAF domain is involved in self-association and is required for the binding of TRAF proteins to their associated receptors (Nakano et al, 1995). See also: MATH domain.
Rothe et al (1994) have divided the TRAF domain into two subregions. The carboxy-terminal TRAF-C domain has been shown to mediate homo- and heterodimerization of TRAF
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