TRICK2B |
trifunctional protein beta subunit |
Immune-induced Molecule 5 |
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[TRAIL receptor without an intracellular domain] This receptor contains a binding site for TRAIL but lacks an intracellular domain (Pan et al, 1997).
TRID expression is detected in many normal human tissues but not in most cancer cell lines examined. Ectopic expression of TRID protectes mammalian cells from apoptosis induced by TRAIL. As TRAIL induces cell death by apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types, it has been suggested that TRID may act as a
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