TRIM68
(approved gene symbol) [tripartite motif-containing protein 68] In databanks the protein is also being referred to as RNF137 [RING finger protein 137]. The cDNA for this protein, termed SS-56, a member of a large family of proteins containing a tripartite motif, has been identified by Billaut-Mulot et al (2001) in a screen for genes downregulated by Murabutide, a drug suppressing HIV1. Billaut-Mulot et al (2001) have reported that anti-SS-56 levels are high in patients with HIV1 infection prior to starting treatment. Most patients with Sjögren syndrome and systemic lupus erythematosus have autoantibodies directed against this protein.
Chang et al (2001) have identified a partial cDNA,
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