TSG-8 |
TSG-21 |
AHWSGHCCL |
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[tumor necrosis factor-stimulated gene sequence-14] TSG-14 was identified originally as one of the TSG genes, genes in a cDNA library derived from TNF-treated normal human FS-4 fibroblasts treated with TNF (Lee et al, 1993). The expression of this gene was inducible by TNF. The gene encodes a glycosylated protein of 381 amino acids, including a hydrophobic signal sequence, which is related to C-reactive protein and serum amyloid P-component, members of the pentaxin family of acute phase proteins. The factor is known also as Pentraxin-3.
TSG-14 mRNA is rapidly induced to high levels in untreated FS-4
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