tabinhibitins |
TAC1 |
4 kDa prothoracicotropic hormone I |
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Tablysin-15 from the salivary gland of the haematophagous horsefly Tabanus yao contains an RGD motif in the N-terminus of the molecule and exhibits high affinity binding for platelet αIIbβ3 and endothelial cell integrin-alpha-V / integrin-beta-3, but not for some other integrins tested (Ma et al, 2011). It blocks endothelial cell adhesion to vitronectin. It also inhibits endothelial cell proliferation in response to bFGF and attenuates tube formation in vitro. Tablysin-15 also inhibits platelet aggregation and attenuates thrombus formation.
See also: Angiogenesis Dictionary
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