Tenecins |
ten eleven translocation proteins |
CD18/CD11c |
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gene symbol Tnc. This secreted Drosophila melanogaster protein encoded by gene CG13648. Tenectin is a hormonally regulated extracellular matrix protein required for proper morphogenesis of the adult wing and male genitalia. Tenectin is a Mucin-type protein that contains an RGD sequence motif and functions as a ligand of the PS2 integrins (Fraichard et al, 2010). Tenectin is a secreted protein that fills the embryonic hindgut lumen during tube diameter expansion and is critical to shape the Drosophila melanogaster hindgut tube (Syed et al, 2012).
Tenectin is required also for the structural and functional integrity of synaptic specializations at the neuromuscular junction. The protein is secreted from
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