Th1-like Th17 cells

this cell type found in humans and mice is considered a subpopulation of Th1 cells that produce both IFN-gamma and IL17 and, therefore, also resemble Th17 cells (Mangan et al, 2006; Acosta-Rodriguezet al, 2007). They produce lower amounts of IL17A than classical Th17 cells but high levels of IFN-gamma (Annunziato et al, 2012). It is thought that these cells derive from Th17 cells in the presence of IL12, TNF-alpha and/or, IL1-beta (Duhen and Campbell, 2014; Maggi et al, 2014; Nistala et al, 2010). These cells express IL23 ... ... ... ...
 
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Entry last modified: April 2020