Tim-3 ligand |
TIM cells |
GpA72 |
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[T-cell membrane protein 4] The approved gene symbol for this protein is TIMD4 [T-cell immunoglobulin and mucin domain-containing 4; T-cell immunoglobulin and mucin domain-containing protein 4]. This protein has been identified independently as SMUCKLER.
Tim-4 encodes a transmembrane protein. The cytoplasmic domain of Tim-4 lacks a conserved tyrosine kinase phosphorylation site found in other TIM family members (see, for example: Tim-3).
Tim-4 is expressed in mouse dendritic cells and macrophages, but not lymphocytes (Meyers et al, 2005). T-cells
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