TsF17.2 |
tsg |
mini-Tryptophanyl-tRNA synthetase |
||
[T suppressor factor for macrophage phagocytosis] The new name given to a factor described first as PIL [phagocytosis-inhibiting lymphokine].
TsFmp is produced by suppressor T-cells, which require in vitro stimulation with specific antigen for factor production. This biochemically uncharacterized factor inhibits the phagocytic activity of a macrophage subset in a lethal infection of mice with Cryptococcus neoformans and in classical models of immune tolerance. The ability of TsFmp to inhibit phagocytosis appears to be limited to engulfment of particles by Fc and mannan receptors and does not affect phagocytosis via complement receptors or by nonspecific mechanisms.
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