Tumor cytotoxic protein |
tumor-derived adhesion factor |
HLA-G7 |
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abbr. TDF (a term with multiple meanings).
This biochemically uncharacterized factor of 30 kDa, which is probably glycosylated, is secreted by human embryonic fibroblasts. Its synthesis is increased by treatment with human IFN-alpha. The coculture of human fibroblasts with KB-cells also augments factor production (Imanishi et al, 1983, 1984, 1985; Tanaka et al, 1988).
Tumor degenerating factor induces degenerative changes in human tumor cells in vitro, including the formation of cell-free areas, and is effective on human KB, HeLa, FL and of hepatoma cells, but not on murine L929,
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