Tumor vascular permeability factor |
Tumstatin7 |
NTPDase-6 |
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a 28 kDa collagen fragment consisting of the NC1 domain of alpha 3 chain of collagen type 4 (referred to as collagen-4-alpha-3 NC1 domain; abbr. also: alpha3(IV)NC1) (corresponding to COL4A3(1445-1669) [collagen-4-alpha-3(1445-1669)]). For similar proteins see also: Arresten, Canstatin, Endostatin, Restin.
The protein has anti-tumor properties and inhibits angiogenesis in an in vivo angiogenesis assay (Matrigel plug assay) (Hamano and Kalluri, 2005). Tumstatin peptides can inhibit the proliferation of endothelial cells in the presence of
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