VEGF family |
VEGFR1 |
Immune-induced Molecule 10 |
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This glycosylated soluble decoy receptor has been designed by Lee et al (2015). VEGF-Grab has the second and third immunoglobulin-like domains of VEGFR1 fused to IgG1 Fc, with three potential glycosylation sites introduced into the third Ig-like domain of VEGF-Grab by mutagenesis. VEGF-Grab can neutralize VEGF-A, VEGF-B, and PlGF. Compared with VEGF-Trap, VEGF-Grab shows more potent decoy activity against VEGF and PlGF and shows less unspecific binding to the extracellular matrix than VEGF-Trap. The decoy receptor shows improved and more durable anti-angiogenic
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