Vgl-4 |
VGLSPG |
HLT2 |
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[vestigial like 4] This is the approved gene symbol for a protein known also as Vgl-4 [Transcription cofactor vestigial-like protein 4]. The cDNA has been cloned independently as KIAA0121. This protein is related to the Drosophila melanogaster vestigial, a protein involved in determining which thoracic imaginal disk cells will form wings and halteres.
VGLL4 is expressed in the heart. It modulates the activity of transcriptional enhancer TEF-1 factors and counteracts alpha-1-adrenergic activation of gene expression in cardiac myocytes (Chen et al, 2004).
Jin et al (2011) have identified VGLL4 as a binding protein for IAP (
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