v-abl |
VAC-alpha |
MTPRGFSCLLLPTSETDLPVKRRT |
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[vacuolating cytotoxin A] Databanks also use the term Vacuolating cytotoxin autotransporter. This virulence factor is encoded by Helicobacter pylori. Its presence is correlated with the severity of H. pylori-induced gastritis.
VacA directly binds to, and is chemotactic for mast cells and induces the production of pro-inflammatory cytokines, TNF-alpha, MIP-1-alpha, IL1-beta, IL6, IL10, and IL13 in these cells without causing degranulation (Supajatura et al, 2002). VacA has been shown to induce cell death by apoptosis in gastric
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