Xotch
[Xenopus Notch 1] This Xenopus laevis gene is a homolog of the Drosophila melanogaster Notch, which in turn is a homolog of human EGF receptor (Coffman et al, 1990). Like Notch, Xotch is involved in cell fate decisions (Coffman et al, 1993) and can functionally replace Notch in Drosophila melanogaster development.
Rones et al (2000) have shown that activation of Xotch by its ligand suppresses cardiomyogenesis. This activity is essential for the correct specification of myocardial and non-myocardial cell fates.
Dorsky et al (2005) have shown that Xotch is expressed in undifferentiated precursor cells
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