YAPC

This human pancreatic cancer cell line was established from the malignant ascites of a patient with pancreatic cancer (Yamada et al, 1998). YAPC cells form tumors in nude mice. The cells secrete a large amount of inflammatory cytokines including IL1-alpha), IL6 and IL8 into the conditioned medium.

The removal of conditioned medium arrests YAPC cell proliferation under the serum-free conditions. Exogenous IL1-alpha stimulates DNA synthesis of the cells and accelerates the progress of cell cycle from G1 to the S phase. ... ... ... ...
 
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Entry last modified: December 2000