Alpha-toxin |
Alpha-trypsin-inhibitor |
p24delta1 |
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abbr. PETCM. This compound has been identified by Jiang X et al (2003) as an activator of caspase-3 in extracts of a panel of cancer cells. PETCM has been shown to relieve Prothymoson-alpha inhibition of caspase-9 activation and allows apoptosome formation at a physiological concentration of dATP. Elimination of prothymosin-alpha expression by RNA interference sensitizes cells to UV-induced apoptosis and obviates the requirement of alpha-(trichloromethyl)-4-pyridineethanol for caspase activation.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary
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