Aorsin |
Aortic endothelial cell growth-inhibitory activity |
glypicans |
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abbr. AGM region. This region, which extends from the umbilicus to the anterior limb bud of the embryo, has been identified in embryonic mice, humans, and birds. It is part of the para-aortic splanchnopleural mesoderm, an anterior lateral region that later contributes to the future aorta, gonads and mesonephros.
The aorta-gonad-mesonephros region is an important intra-embryonic site of primitive hematopoiesis and serves as the first supportive microenvironment supporting hematopoietic stem cell development. During mouse development, the first definitive hematopoietic stem cells are detected in the aorta-gonad-mesonephros region at E10.5 (Müller et al, 1994). The budding of hematopoietic cells from
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