atypical squamous cells cannot exclude HSIL |
atypical squamous cells of undetermined significance favor neoplasia |
NA neurons |
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[atypical squamous cell of undetermined significance]
abbr. ASCUS. This term pertains in particular to lesions of the cervical epithelium, detectable by cytological examination (Papanicolaou smear or liquid-based cervical cytology; note that the Pap smear is a screening method, not a diagnostic tool). The term is used by histologists/pathologists for atypical cells that cannot be classified easily as benign, suspicious, or malignant (Nguyen and Nordqvist, 1999). The term reflects diagnostic uncertainty (see, for example, Briselli et al, 1995; Pitman et al, 2002) and ASCUS findings require either repeated cytological follow-up or additional tests such as screening for human papilloma virus or immunological tests (Massad et al, 2013; Laudadio J, 2013; Roelens Jet al, 2013), which can be used to distinguish cases with
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