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basket cells

This term has been used in several different ways.

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(-1-)

these cells are specialized neurons (interneurons) in the neocortex first described by Ramon y Cajal (Ramon y Cajal, 1911) and named after their distinct axonal arborizations on and around somata of target neurons (Somogyi et al, 1983; Jones and Hendry, 1984; Casteyon et al, 2001). Three distinct types of neocortical basket cells have been described: large basket cells, small basket cells, and nest basket cells. Nest basket cells form simpler dendritic arbors and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches.

These three cell types differ in morphology and immunoreactivities for different calcium binding proteins and neuropeptides. Small basket cells have been shown to lack NPY expression but invariably express VIP. Large basket cells do not express VIP, calretinin or somatostatin. Nest basket cells do not express VIP and calretinin (Wang et al, 2002). Differences are seen also in the electrophysiologic behavior of these cells and the connections they make. The functional significance or the organizational principles underlying this diversity are not known.

For other relevant entries see also: Cell types.

LAST MODIFIED: October 2006

REFERENCES: Castejon OJ et al Light microscopy, confocal laser scanning microscopy, scanning and transmission electron microscopy of cerebellar basket cells. Journal of Submicroscopic Cytology and Pathology 33(1-2): 23-32 (2001); Jones EG and Hendry SHC Basket cells. In: Cerebral cortex: cellular components of the cerebral cortex (Peters A, Jones EG, editors), pp. 309-334. New York: Plenum Press, (1984); Ramon y Cajal S Histologie de systeme nerveux de l'homme et des vertebres. Tomme II. Paris: Maloine. (1911); Somogyi P et al Synaptic connections of morphologically identified and physiologically characterized large basket cells in the striate cortex of cat. Neuroscience 10: 261-294 (1983); Wang Y et al Anatomical, physiological, molecular and circuit properties of nest basket cells in the developing somatosensory cortex. Cerebral Cortex 12(4): 395-410 (2002)

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(-2-)

These cells are contractile myoepithelial cells (smooth muscle cells) characterized by a dendritic basket-like structure in the periphery of acini and ducts of serous glands (Caselitz et al, 1986; Mir-Salim et al, 1998; Soloff et al, 1980; Warburton et al, 1982; Watanabe, 1980; Zedda and Farina,1998).

For other relevant entries see also: Cell types.

LAST MODIFIED: October 2006

REFERENCES: Caselitz J et al Immunohistochemical investigations on the epimyoepithelial islands in lymphoepithelial lesions. Use of monoclonal keratin antibodies. Laboratory Investigation 55(4): 427-432 (1986); Mir-Salim PA et al [Glands of the human nasal mucosa--electron microscopy and immunohistochemical studies] Laryngorhinootologie. 77(6): 322-327 (1998); Soloff MS et al Purification and characterization of mammary myoepithelial and secretory cells from the lactating rat. Endocrinology 106(3): 887-897 (1980); Warburton MJ et al Distribution of myoepithelial cells and basement membrane proteins in the resting, pregnant, lactating, and involuting rat mammary gland. Journal of Histochemistry and Cytochemistry 30(7): 667-676 (1982); Watanabe M An autoradiographic, biochemical, and morphological study of the harderian gland of the mouse. Journal of Morphology 163(3): 349-365 (1980); Zedda M and Farina V Immunocytochemical identification of different cell types in bovine nasolabial glands with particular emphasis on cytoskeletal protein expression. Anatomy Histology and Embryology 27(1): 37-44 (1998)

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(-3-)

These cells, called also shadow cells of Gumprecht or Gumprecht's shadow cells, are seen in blood films from patients with lymphoproliferative syndromes and particularly in chronic lymphocytic leukemia (CLL). A statistically significant correlation between the numbers of basket cells and lymphoctres with dense chromatin, and the anatomic-clinical stage of the disease does not exist. These cells are considered spreading artefacts, which are produced during the preparation of blood film slide (Binet et al, 1993).

LAST MODIFIED: October 2006

REFERENCES: Binet JL et al Basket cells or shadow cells of Gumprecht: a scanning electron microscope study, and the correlation between percentages of basket cells, and cells with altered chromatin structure (dense cells), in chronic lymphocytic leukemia. Blood Cells 19(3): 573-581; discussion 582-589 (1993)

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