cact |
CACY |
smtlb |
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symbol: cact. This Drosophila melanogaster gene, encoded by gene CG5848, has been identified by Geisler et al (1992). The protein is considered the fly homolog of I-kappa-B [Inhibitor of NF-kappa-B]. Cactus has been shown to inhibit DNA binding of the morphogen dorsal (Geisler et al, 1992; Kidd, 1992), suggesting that it is involved in dorsoventral patterning. Cactus inhibits nuclear translocation of dorsal in the dorsal region of the embryo.
Cactus also acts as a negative regulator of the NF-kappa-B (relish) signaling pathway (Govind, 1999). Toll
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