casein-beta(80-90) |
casein-beta(94-123) |
Callatostatin-1 |
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Also: beta-casein(84-86). This peptide with the sequence VPP (Val-Pro-Pro) is derived from bovine casein-beta (Nakamura et al, 1995) and has been shown to be an inhibitor for angiotensin-1 converting enzyme (CD143) that can lower blood pressure (de Leeuw et al, 2009; Nakamura et al, 2011). Hirota et al (2011) have reported that induces nitric oxide production in cultured vascular endothelial cells and isolated arterial vessels. The peptide induces endothelium-dependent relaxation of isolated aortic rings, and these effects can be inhibited by NO synthase inhibitors, potassium channel inhibitors, and bradykinin B2 receptor antagonists.
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