Cyclosporin A binding protein |
CYCRIPACIAGERRYGTCIYQGRLWAFCC |
EMCV 2C protein |
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[cyclopeptidic vascular endothelial growth inhibitor] This cyclic peptide (DFPQIMRIKPHQGQHIGE; also: d-Phe-Pro79-93) is derived from VEGF residues 79-93 (VEGF(79-93)), which are involved in the interaction of VEGF with receptor-2 (KDR) (Zilberberg et al, 2003). The compound is known also as CBO-P11. The linear form of cyclo-VEGI (PQIMRIKPHQGQHIGE) has no biological activity and does not compete with VEGF for receptor binding
Cyclo-VEGI has been shown to inhibit binding of VEGF-165 to endothelial cells, proliferation of endothelial cells, migration and signaling induced by
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