Dark microglia |
dark-pigmentotropin |
TBM cells |
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[dark neuron]
[dramatically shrunken and hyperbasophilic neurons]. This histological term refers to neurons with signs of degeneration (pyknosis and hyperchromatosis). Sugimoto et al (1990) have described three principal characteristics of dark neurons: (a) irregular cellular outlines; (b) increased amounts of chromatin throughout the nucleoplasm and cytoplasm (which is why they are called dark neurons); and (3) intensely and homogeneously stained nucleoplasm with almost indiscernible heterochromatin. These cells are thought to be generated in vivo as an acute or delayed consequence of several pathological situations and lesions and have been reported to show ultrastructural features of necrosis and apoptosis (see also: aponecrosis, necrapoptosis
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