DBI(43-50) |
Dbl homology domain |
I-kappa-B-alpha |
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[defective body length-1] This gene from Caenorhabditis elegans encodes a homolog of TGF-beta (Suzuki et al, 1999). It is known also as CET-1 (Morita et al, 1999).
Savage-Dunn et al (2003) have studied TGF-beta signaling components in the nematode and have reported that TGF-beta signaling pathways are quite conserved.
The dbl-1 gene controls body shape in a dose-dependent manner. Loss-of-function mutations cause a short, small body, whereas overexpression causes a long body (Suzuki et al, 1999).
dbl-1 plays a role in innate immunity
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