DRO1 |
D-Robo1 |
interleukin-17 receptor C(376-387) |
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Drob-1 is a Drosophila melanogaster protein related to members of mammalian BCL2. The protein contains conserved BCL2 homology domains (BH1, BH2, BH3, and BH4) and a C-terminal hydrophobic domain. It is localized predominantly to mitochondrial membranes. drob-1 has been described independently as dBorg-1, Debcl, and Dbok.
Ectopic expression of Drob-1 in the developing Drosophila melanogaster eye results in a rough-eye phenotype. Overexpression of the protein in Drosophila melanogaster S2 cells, induces cell death by apoptosis
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