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foam cells

Foam cells develop from macrophages that have ingested oxidized low density lipoprotein by a variety of endocytic pathways (Itabe and Takano, 2000). These macrophages help or hinder cholesterol removal from vessel walls in atherosclerotic lesions (Kruth, 2001).

These cells have been described also as lipophages. They are being referred to also as xanthoma cells and have been called foamy macrophages or foamy histiocytes.

The term is used also in a more general sense to denote other cell types that are lipid-laden. For example, IGF-1 induces mesangial cells to take on a foam cell morphology and these lipid-laden cells have impaired phagocytic function (Berfield and Abrass, 2002).

For related information see also: Cell types, Cell lines in Cytokine Research, Cell culture.


LAST MODIFIED: January 2007

See REFERENCES for entry foam cells

foam cells

The following COPE entries contain this entry term or one of its hypertext synonyms:

AIM, CD68, cell types, Cyclophilin A, EMAP-2, fibrocytes, foamy histiocytes, foamy macrophages, HIAP1, histiocytes, lipophages, macrophages, monocytes, p43, SAA, TIMP-3, Touton giant cells, TWEAK, xanthoma cells.

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