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gas-11

[Growth arrest-specific gene-11] gas-11 is one of the growth arrest-specific genes identified in quiescent, serum-starved NIH 3T3 mouse fibroblasts (see: gas genes).

Human and murine gas-11 proteins are 96 % identical. The human gene maps to chromosome 16q24.3 and may function as a tumor suppressor gene in human breast cancer. There are two different mRNAs expressed ubiquitously in heart and skeletal muscle. One transcript appears to be expressed in skeletal muscle alone.

gas-11 seems to represent the mammalian counterpart of TLTF [trypanosome lymphocyte-triggering factor], an ... ... ... ... ... Subscribe to continue reading! ... ...

 

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