gp200-MR6
In the nomenclature of CD antigens this protein has been given the designation CD205.
This glycoprotein of 200 kDa is recognised by monoclonal antibody MR6, which was raised against human thymic cortical epithelial cells but was found also to show weaker reactions with lymphocytes, dendritic cells, macrophages, and some non-thymic epithelia (DeMaagd et al, 1985; von Gaudecker et al, 1997).
The addition of the monoclonal antibody to in vitro assays blocks the proliferation of cloned T-cells induced by IL4 and the IL4-dependent switch to IgE in allergen-stimulated B-cells
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