Cytokines & Cells Online Pathfinder Encyclopaedia
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abbr. HTH motif. The helix-turn-helix motif is detected in many transcription regulators (Brennan and Matthews; Wintjens and Rooman; Rosinski and Atchley). It is a ubiquitous DNA-binding motif that is usually incorporated into several structural scaffolds. Proteins containing this motif have been subgrouped into at least 30 different protein families.
For information on other protein domains and sequence motifs see also the Protein domains Dictionary section of this encyclopedia.
LAST MODIFIED: August 2003
See REFERENCES for entry helix-turn-helix motif
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