humoral recognition factor |
HUMSTR |
Lactoferrin peptide 2 |
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abbr. HSA (a term with multiple meanings). This term describes an activity found in the serum of AML (acute myeloid leukemia) following treatment with cytotoxic antimetabolites (ara-C). This activity is responsible for the increased proliferation and an enhanced metabolization of the antimetabolite observed after an initial period of cytoreduction. Increased metabolization of araC then inhibits DNA synthesis in the growing cells.
It is assumed that several different cytokines are responsible for this activity but none of them have been investigated in detail.
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