Iasi congenital atrichia |
iASPP/RAI |
CXC-Chemokine receptor 2 |
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[inhibitory member of the ASPP family; inhibitor of Apoptosis Stimulating p53 Protein] This protein is an evolutionarily conserved inhibitor of p53 (Bergamaschi et al, 2003). It is encoded by PPP1R13L [protein phosphatase 1 regulatory subunit 13 like] in humans and has been identified independently as RAI (RelA-associated inhibitor), which binds to the NF-kappa-B subunit p65 (RelA) and inhibits the activity of this transcription factor (Yang et al, 1999).
The corresponding mouse gene, termed Nkip1 [NF-kappa-B interacting protein 1
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