intrahepatic biliary epithelial cells |
intraluminal splitting angiogenesis |
HHIPL2 |
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[intracellular chemokine] this term refers to a strategy essentially producing a knock-out phenotype for a (cytokine) receptor by blocking the cell surface expression of newly synthesized receptor proteins (Yang et al, 1998). Engel et al (2000) have observed that an intrakine (an engineered form of SDF-1-alpha) may also be secreted and cause the downregulation of the corresponding receptor by acting like a secreted chemokine.
In one case a member of the chemokines (CC-Chemokines) (the intrakine; see also: Recombinant cytokines, Muteins) was targeted to the endoplasmic reticulum where the corresponding receptor is synthesized before it is transported to the plasma membrane. This is achieved by fusion of the
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