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myeloid leukemia cell differentiation factor

This of 54.3 kDa is produced by human lymphocytes (Xu and Chiao, 1996). Xu et al (1996) have reported that the factor is identical with neuroleukin, which is identical with phosphohexose isomerase. The purified factor also possesses enzymatic activity.

The factor mediates the differentiation of human myeloid leukemia cells HL-60 to monocytic cells. The purified inducer causes growth reduction and differentiation of leukemia cells to mature monocytes and macrophages.

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