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abbr. NID. Also: death by neglect. Both terms have been used frequently in the context of thymocyte development and maturation that eventually yields functionally mature T-cells (Chung et al, 2002; Grebe et al, 2004; Krueger et al, 2003; Li et al, 2005; Minter and Osborne, 2003; Srivastava et al, 2007). Positive selection leads to the emergence of thymocyte populations that are single-positive either for CD4 or CD8 and bear functional T-cell antigen receptors remain. Potentially useless or autoreactive thymocytes are eliminated and are said to undergo death by neglect. Double-positive thymocytes that fail to interact with thymic epithelial cells
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