Nephroblastoma overexpressed gene |
Nephrocan |
PDNP2 |
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This bioactive peptide fragment (see also: cryptides) is derived from nov [Nephroblastoma overexpressed gene], a member of the CCN family of secreted cysteine-rich growth regulators (Karagiannis and Popel, 2007). Nephroblastostatin [nov(211-228)] [TEWTACSKSCGMGFSTRV] corresponds to residues 211-228 of the nov gene (Karagiannis and Popel, 2008). The primary structure of this peptide is similar to the thrombospondin type 1 domains found in thrombospondin-1, thrombospondin-2, the metalloproteinases ADAMTS1 and ADAMTS8. The peptide functions as an inhibitor of
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