netrin-G1 ligand |
Netrin-G2 ligand |
KSHV orf50 |
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approved gene symbol: NTNG2. The cDNA has been cloned independently as KIAA1857.
Netrin-G2 has been identified independently as Laminet-2. Meerabux JM et al (2005) have reported the exon/intron structure of the human netrin-G2 gene. Mouse netrin-G2 has been identified by Nakashiba et al (2002).
Unlike classical netrins, which are secreted proteins, Netrin-G2 is anchored to the cell surface by a glycosyl-phosphatidyl-inositol linkage. Netrin-G2 lacks affinity to classical receptors for netrins. Netrin-G2 is expressed preferentially in the brain and shows an expression pattern complementary to that of the related netrin-G1.
Netrin-G2 may provided short-range
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