Netrins |
netrinstatin-5D |
neosulfakinin I |
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This peptide (Karagiannis and Popel, 2007) is derived from the netrin receptor UNC5C (UNC5H3). Netrinstatin-5C [TEWSVCNSRCGRGYQKRTR] corresponds to residues 267-285 or the UNC5C gene (UNC5C(267-285); UNC5H3(267-285)) (Karagiannis and Popel, 2008). The primary structure of this peptide is similar to the thrombospondin type 1 domains found in thrombospondin-1, thrombospondin-2, the metalloproteinases ADAMTS1 and ADAMTS8. The peptide functions as an inhibitor of angiogenesis and has been shown to inhibit proliferation and migration of human
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