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p14ARF(1-22)

also: ARF(1-22). This peptide, MVRRFLVTLRIRRACGPPRVRV, corresponds to amino acids 1-22 of p14ARF, a tumor suppressor the expression of which is widely deregulated in many types of cancers and which is believed to function as a failsafe mechanism, inhibiting proliferation and inducing apoptosis as cellular response to a high oncogene load. The peptide mimics the function of the full-lentgth protein (Lohrum et al, 2000; Midgley et al, 2000).

Johansson et al (2008) have reported that p14ARF(1-22) is a cytotoxic cell-penetrating peptide. The peptide is internalized to the same extent as the cell-penetrating peptide TP10 peptide (see: Transportan ... ... ... ... ... Subscribe to continue reading! ... ...

 

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