p43 placenta isoferritin |
p44ERK1 |
Htu |
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[p43 placenta isoferritin] This placental protein with immunoregulatory activity (Moroz et al, 1985) is identical with a protein described independently as PLIF [placenta immunomodulatory ferritin] (Moroz et al, 2002) and is composed of an incomplete ferritin heavy chain sequence (amino acids 1-117) linked to a novel non-ferritin 48 amino acid domain named C48 (amino acids 118-165).
p43-PLF protein is highly expressed in human syncytiotrophoblasts, Hofbauer cells, and in decidual macrophages (Maymon et al, 2000). During normal pregnancy p43-PLF levels are elevated early in maternal circulation and decline at term (Maymon and Moroz, 1996). p43-PLF are low or below detection in
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