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pore-induced intracellular traps

[pore-induced intracellular trap]

abbr. PITs. These structures have been observed by Jorgensen et al (2016) in macrophages undergoing lytic cell death such as pyroptosis. Pore-induced intracellular traps are conceptually parallel to neutrophil extracellular traps and trap viable intracellular bacteria within the cellular debris. Pore-induced intracellular traps coordinates innate immune responses via complement and scavenger receptors to drive recruitment of, and efferocytosis by, neutrophils, killing the entrapped micro-organisms. The existence of this mechanism also suggests that bona fide intracellular bacterial pathogens, such as Salmonella typhimurium and Listeria monocytogenes, must prevent or delay ... ... ... ... ... Subscribe to continue reading! ... ...

 

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