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preapoptotic cell stress response

abbr. PACSR. This term pertains to processes observed in primary hepatocytes shortly after their isolation (Nipic D et al, 2010). Essentially, these changes refer to the translocation of the proform of caspase-9 and BAX from the cytoplasm to the nuclei as well as to a dispersion of mitochondria and are thought to reflect cell stress in freshly isolated cells subjected to tissue culture.

The observed changes appear similar to those at the beginning of apoptosis; however, the isolated hepatocytes are viable and not apoptotic. The authors have proposed that the translocation of the proform of caspase-9 and BAX into nuclei may reduce the ability to trigger apoptosis ... ... ... ... ... Subscribe to continue reading! ... ...

 

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