Pro-Glu-Asp-Gln-Glu-Leu-Glu-Ser-Leu-Ser-Ala-Ile-Glu-Ala-Glu-Leu-Glu-Lys-Val-Ala-His-Gln-Leu-Gln-Ala-Leu |
proglucagon(1-30) |
fes |
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see: glucagon. Differential processing of the proglucagon sequence in A-cells (glucagon cells) of pancreatic islets and intestinal endocrine L cells yields different products (for review see also: Holst, 2010).
Pancreatic A-cell process proglucagon mainly to glucagon, GRPP [glicentin-related pancreatic peptide] and MPGF [major proglucagon fragment] (encompassing the GLP-1 and GLP-2 sequences) (Patzelt and Schiltz, 1984; Patzelt et al, 1979). 10 to 20 % of the MPGF is further processed to GLP-1 (Holst et al, 1994). In intestinal L cells
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