prokineticin-2
approved gene symbol: PROK2. abbr. also PK2.
The cDNAs for this secreted protein (81 amino acids) and another protein, termed prokineticin-1, have been cloned based on their sequence similarity to a frog skin secretion protein, Bv8, and a nontoxic protein of mamba snake venom (Li et al, 2001). The protein is being referred to also as Bv8 homolog. The gene is expressed in the gastrointestinal tract, particularly the stomach. Prokineticin-2 potently and specifically contracts gastrointestinal smooth muscle at subnanomolar range. The protein does not have an effect on vascular or respiratory smooth muscle. For an invertebrate homolog see also:
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