Protein HC |
protein inhibitor of activated STAT |
death effector domains |
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protein I/II is a cell wall-anchored, multiligand binding adhesin with a high molecular weight of the oral pathogen Streptococcus mutans. This adhesin also acts as a modulin that induces cytokine production in various cell types. One of the receptors for protein I/II on endothelial cells has been identified as integrin-alpha-5 / integrin-beta-1 (Al-Okla et al, 1999).
Vernier et al (1996) have reported that binding of the adhesin to eukaryotic cells initiates the release of IL8 from KB-cells and of IL6 and IL8 from endothelial cells. In endothelial cells, protein I/II modulates the expression of
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