recombinant cytokines
[recombinant cytokine]
Sources for human (and other) cytokines are extremely poor and the expression of these factors may vary considerably, depending on the physiological state of the body. Generally, levels are too low to be considered good sources of factors for clinical use. As an example, 8.5 mg of M-CSF have been isolated from 10000 L of human urine.
Recombinant cytokines, i.e., cytokines produced by expression from suitable cloning vectors containing the desired cytokine gene, can be expressed in yeast (see: Saccharomyces cerevisiae expression system), bacteria (see: Escherichia coli expression system),
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