shifted
abbr. shf, encoded by gene CG3135. This is the Drosophila melanogaster ortholog of WIF-1 [Wnt-inhibitory factor-1] (Gorfinkiel et al, 2005). It is being referred to also as WIF-1-like protein. Shifted is a secreted protein that acts as a modulator of Hedgehog signaling in the developing wing imaginal disc. Unlike mammalian Wnt-1, shifted does not bind to extracellular Wnt proteins and inhibit their activity (Glise et al, 2005).
Gorfinkiel et al (2005) have shown that shifted is required for hedgehog stability and for lipid-modified hedgehog diffusion. Shifted colocalizes with
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